An additional test was performed 12Â hours after 10000Â cycles. Moments (Â☗.5Â Nm) were applied in flexion-extension (FE), lateral bending (LB) and axial rotation (AR) at 1Hz for total 10000Â cycles in MTS Bionix. Three 元/4 synthetic spinal motion segments were examined using a validated pure moment testing system. The goal of current study is to evaluate the properties of a synthetic biomimetic spine model also to assess the mechanical performance of lateral plating following lateral interbody fusion. Therefore, a synthetic biomimetic spine model may be an acceptable substitute. Laboratory spinal biomechanical tests using human cadaveric or animal spines have limitations in terms of disease transmission, high sample variability, decay and fatigue during extended testing protocols. Wang, Tian Ball, Jonathon R Pelletier, Mattew H Walsh, William R We review the relevant biomechanical properties of spinal cord tissue and provide the baseline knowledge required to apply these important physical concepts to spinal cord tissue engineering.īiomechanical evaluation of a biomimetic spinal construct. Given that a number of regenerative strategies aim to deliver cells and materials in the form of tissue-engineered therapies, understanding the biomechanical properties of host spinal cord tissue is important. Previous research has focused primarily on exploring the cellular and biological aspects of the spinal cord, yet relatively little remains known about the biomechanical properties of spinal cord tissue. Regenerative medicine may offer a promising solution to this problem. Spinal cord injury is a severely debilitating condition which can leave individuals paralyzed and suffering from autonomic dysfunction. This work demonstrates that iatrogenic damage to spinal ligaments disturbs the load sharing within the spinal ligament network and may induce significant clinically relevant changes in the spinal motion segment.īiomechanical properties of the spinal cord: implications for tissue engineering and clinical translation.īartlett, Richard D Choi, David Phillips, James B All major biomechanical changes occurred at the same spinal level as the transected ligament, with minor changes at adjacent levels. Once a ligament was removed, stress increased in the remaining spinal ligaments and changes occurred in vertebral strain energy, but disc pressure remained similar.
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A finite element model of the full lumbar spine was developed and validated against experimental data and tested in the primary modes of spinal motion in the intact condition. The purpose of this work was to quantify the previously unknown biomechanical consequences of isolated spinal ligament transection on the remaining spinal ligaments (stress transfer), vertebrae (bone remodelling stimulus) and intervertebral discs (disc pressure) of the lumbar spine. Many lumbar spine surgeries either intentionally or inadvertently damage or transect spinal ligaments. Biomechanical implications of lumbar spinal ligament transection.